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Article

The role of TSC1 and TSC2 proteins in neuronal axons.

Molecular psychiatry - 1 Apr 2024

Karalis Vasiliki, Wood Delaney, Teaney Nicole A, Sahin Mustafa

Abstract excerpt

Tuberous Sclerosis Complex 1 and 2 proteins, TSC1 and TSC2 respectively, participate in a multiprotein complex with a crucial role for the proper development and function of the nervous system. This complex primarily acts as an inhibitor of the mechanistic target of rapamycin (mTOR) kinase, and mutations in either TSC1 or TSC2 cause a neurodevelopmental disorder called Tuberous Sclerosis Complex (TSC)....

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Topics

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Share to Signal Transduction
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TOR Serine-Threonine Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 38212374
DOI: 10.1038/s41380-023-02402-7
PMCID: PMC12863650

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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