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Article

UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration

29 Sept 2015

Abstract excerpt

Neurodegenerative diseases are a leading cause of disability and early death. A common feature of these conditions is disruption of protein homeostasis. Ubiquitin-like modifier activating enzyme 1 (UBA1), the E1 ubiquitin-activating enzyme, sits at the apex of the ubiquitin cascade and represents an important regulator of cellular protein homeostasis. Critical contributions of UBA1-dependent pathways to the...

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PMID: 26432019
DOI: 10.1016/j.molmed.2015.08.003

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