Article
The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis.
Autophagy - 1 Jan 2015
Zhao Yan G, Sun Le, Miao Guangyan, Ji Cuicui, Zhao Hongyu, Sun Huayu, Miao Lin, Yoshii Saori R, Mizushima Noboru, Wang Xiaoqun, Zhang Hong
Abstract excerpt
WDR45/WIPI4, encoding a WD40 repeat-containing PtdIns(3)P binding protein, is essential for the basal autophagy pathway. Mutations in WDR45 cause the neurodegenerative disease β-propeller protein-associated neurodegeneration (BPAN), a subtype of NBIA. We generated CNS-specific Wdr45 knockout mice, which exhibit poor motor coordination, greatly impaired learning and memory, and extensive axon swelling with...
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