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Article

The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice.

Proceedings of the National Academy of Sciences of the United States of America - 3 Dec 2019

Minis Adi, Rodriguez Jose A, Levin Avi, Liu Kai, Govek Eve-Ellen, Hatten Mary E, Steller Hermann

Abstract excerpt

Proteasome-mediated degradation of intracellular proteins is essential for cell function and survival. The proteasome-binding protein PI31 (Proteasomal Inhibitor of 31kD) promotes 26S assembly and functions as an adapter for proteasome transport in axons. As localized protein synthesis and degradation is especially critical in neurons, we generated a conditional loss of PI31 in spinal motor neurons (MNs) and...

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Identifiers

PMID: 31754024
DOI: 10.1073/pnas.1911921116
PMCID: PMC6900516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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