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Article

The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance and neuronal survival in mice

2019-07-22

Abstract excerpt

Proteasome-mediated degradation of intracellular proteins is essential for cell function and survival. The proteasome-binding protein PI31 (Proteasomal Inhibitor of 31kD) promotes 26S assembly and functions as an adapter for proteasome transport in axons. As localized protein synthesis and degradation is especially critical in neurons, we generated a conditional loss of PI31 in spinal motor neurons (MNs) and cereb...

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Identifiers and source

Literature Corpus work
09ed06a4-5964-5b85-9fa5-c197b45662a8
DOI
10.1101/711515
Open publication

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The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance and neuronal survival in miceDOI 10.1101/711515
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