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Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation

23 Feb 2021

Abstract excerpt

Hereditary spastic paraplegia (HSP) denotes genetically heterogeneous disorders characterized by leg spasticity due to degeneration of corticospinal axons. SPG11 and SPG15 have a similar clinical course and together are the most prevalent autosomal recessive HSP entity. The respective proteins play a role for macroautophagy/autophagy and autophagic lysosome reformation (ALR). Here, we report that spg11 and...

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PMID: 33618608
DOI: 10.1080/15548627.2021.1891848

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