Alternative lipid synthesis in response to phosphate limitation promotes antibiotic tolerance in Gram-negative ESKAPE pathogens

Abstract excerpt

The Gram-negative outer membrane protects bacterial cells from environmental toxins such as antibiotics. The outer membrane lipid bilayer is asymmetric; while glycerophospholipids compose the periplasmic facing leaflet, the surface layer is enriched with phosphate-containing lipopolysaccharides. The anionic phosphates that decorate the cell surface promote electrostatic interactions with cationic antimicrobial pep...

Topics

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• Alkaline Phosphatase
• Antibiotic Resistance in Bacteria
• Bacteria
• Bacterial Infections and Vaccines
• Drug Resistance, Bacterial
• Lipid A
• Models, Molecular
• Mutation

Identifiers and source

Literature Corpus work

10c455c6-19a6-503b-b6ea-d78aae2fc372

DOI

10.1101/2024.09.11.612458