Article

Fatty acid biosynthesis inhibitors fabimycin and triclosan trigger distinct resistance mutations in FabI and potently kill Gram-negative pathogens

2026-04-06

Abstract excerpt

<h4>ABSTRACT</h4> In the effort to develop efficacious antibacterials that engage targets for which there is no pre-existing resistance, inhibition of the enoyl-acyl carrier protein reductase FabI has shown promise, with triclosan and fabimycin as representative members of the two major drug classes that show activity against important bacterial pathogens. Here, we use a morbidostat and whole genome sequencing to...

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Literature Corpus work: aef3ed96-7e32-5405-82b4-383998e595d5
DOI: 10.64898/2026.04.05.716606

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Fatty acid biosynthesis inhibitors fabimycin and triclosan trigger distinct resistance mutations in FabI and potently kill Gram-negative pathogensDOI 10.64898/2026.04.05.716606Read

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