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Article

Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.

ACS infectious diseases - 8 Jul 2016

McKinney David C, Eyermann Charles J, Gu Rong-Fang, Hu Jun, Kazmirski Steven L, Lahiri Sushmita D, McKenzie Andrew R, Shapiro Adam B, Breault Gloria

Abstract excerpt

Fatty acid biosynthesis is essential to bacterial growth in Gram-negative pathogens. Several small molecules identified through a combination of high-throughput and fragment screening were cocrystallized with FabH (β-ketoacyl-acyl carrier protein synthase III) from Escherichia coli and Streptococcus pneumoniae. Structure-based drug design was used to merge several scaffolds to provide a new class of inhibitors....

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Source

Identifiers

PMID: 27626097
DOI: 10.1021/acsinfecdis.6b00053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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