[Kidney diseases associated with uromodulin (Tamm-Horsfall protein)].

Abstract excerpt

Uromodulin is the most abundant protein excreted in the urine under physiological conditions. It is exclusively expressed in the kidney by epithelial cells lining the thick ascending limb of Henles loop. It is mainly localized at the apical plasma membrane of tubular cells and released through a proteolytic cleavage. Although its function is still elusive it is proposed to have a protective role against urinary...

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