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Article

Uromodulin biology and pathophysiology--an update.

Kidney & blood pressure research - 1 Jan 2010

Vyletal Petr, Bleyer Anthony J, Kmoch Stanislav

Abstract excerpt

Uromodulin (UMOD) is a glycoprotein expressed on the luminal surface of the apical membrane of renal tubular epithelial cells forming the thick ascending limb of Henle. Here, UMOD forms filamentous structures probably ensuring water impermeability and the countercurrent gradient. The multidomain structure, cellular topology of UMOD and clinical consequences associated with UMOD dysfunction, however, suggest that...

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Identifiers

PMID: 21109754
DOI: 10.1159/000321013

Genes

UMOD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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