Article
Evidence for a role of uromodulin in chronic kidney disease progression.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jun 2010
Prajczer Sinikka, Heidenreich Ursula, Pfaller Walter, Kotanko Peter, Lhotta Karl, Jennings Paul
Abstract excerpt
BACKGROUND: Uromodulin (also known as Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals and exhibits diverse functions including prevention of ascending urinary tract infections by binding type I-fimbriated Escherichia coli. Although uromodulin is targeted to the apical membrane of thick ascending limb (TAL) cells and secreted into the lumen, detectable levels are also found in...
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