Article
[Uromodulin - can it be a new marker of kidney damage?].
Przeglad lekarski - 1 Jan 2013
Fugiel Andrzej, Kuzniewski Marek, Fedak Danuta
Abstract excerpt
Uromodulin (Tamm-Horsfall protein) is the most abundant protein excreted in the urine under physiological conditions. It is exclusively produced in the kidney and secreted into the urine via proteolytic cleavage. Its biological function is stillnot fully understood. Uromodulin has been linked to waterl electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a...
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