IMMClock reveals immune aging and T cell function at single-cell resolution

Abstract excerpt

The aging of the immune system substantially impacts individual immune responses, yet accurately quantifying immune age remains a complex challenge. Here we developed IMMClock , a novel immune aging clock that uses gene expression data to predict the biological age of individual CD8⁺ T cells, CD4⁺ T cells, and NK cells. The accuracy of IMMClock is first validated across multiple independent datasets, demonstratin...

Topics

Open a Topic to create a Post that cites this publication.

• CD4-Positive T-Lymphocytes
• Cellular Senescence
• Immunologic Memory
• Lymphocyte Activation
• Receptors, Antigen, T-Cell
• Sequence Analysis, RNA
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

7f4084f5-adc9-5d1d-971d-a49aa8010689

DOI

10.1101/2024.11.13.623449