Article

Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses

2020-08-14

Abstract excerpt

Respiratory virus infection is one of the leading causes of death in the world. Activation of the Jak-Stat pathway by Interferon-alpha/beta (IFN- α / β ) in lung epithelial cells is critical for innate immunity to respiratory viruses. Genetic and biochemical studies have shown that transcriptional regulation by IFN- α / β required the formation of Interferon-stimulated gene factor-3 (ISGF-3) complex consisting...

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Literature Corpus work: 7f407b1b-d1fe-5b72-a0ba-26e67a26129c
DOI: 10.1101/2020.08.14.244897

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