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Article

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

18 Mar 2016

Abstract excerpt

In the canonical pathway of IFN-I-mediated signaling, phosphorylation of STAT1 and STAT2 leads to heterodimerization and interaction with IRF9. This complex, also known as IFN-stimulated gene factor 3 (ISGF3), then translocates into the nucleus and binds the IFN-I-stimulated response element (ISRE) leading to the activation of transcription of over 300 interferon stimulated genes (ISGs). In addition, STAT1...

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PMID: 27053489
DOI: 10.1016/j.cytogfr.2016.02.010

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