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Article

Cutting edge: a critical role for gene silencing in preventing excessive type 1 immunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2005

Hutchins Anne S, Artis David, Hendrich Brian D, Bird Adrian P, Scott Phillip, Reiner Steven L

Abstract excerpt

Immunity often depends on proper cell fate choice by helper T lymphocytes. A naive cell, with minimal expression of IFN-gamma and IL-4, must give rise to progeny expressing high levels of either one, but not both, of those cytokines to defend against protozoan and helminthic pathogens, respectively. In the present study, we show that inactivation of the Mbd2 gene, which links DNA methylation and repressed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16237047
DOI: 10.4049/jimmunol.175.9.5606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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