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Chronic Helminth Infection Promotes Immune Regulation In Vivo through Dominance of CD11cloCD103− Dendritic Cells

17 May 2011

Abstract excerpt

Gastrointestinal helminth infections are extremely prevalent in many human populations and are associated with downmodulated immune responsiveness. In the experimental model system of Heligmosomoides polygyrus, a chronic infection establishes in mice, accompanied by a modulated Th2 response and increased regulatory T cell (Treg) activity. To determine if dendritic cell (DC) populations in the lymph nodes draining...

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PMID: 21576507
DOI: 10.4049/jimmunol.1003636

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