Article

First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancer

2022-02-24

Abstract excerpt

The footprint left by early cancer dynamics on the spatial arrangement of tumour cells is poorly understood, and yet could encode information about how therapy resistant sub-clones grew within the expanding tumour. Novel methods of quantifying spatial tumour data at the cellular scale are required to link evolutionary dynamics to the resulting spatial architecture of the tumour. Here, we propose a framework using...

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Literature Corpus work: 7f1738be-0c6b-5233-9b06-a99159e4e555
DOI: 10.1101/2022.02.22.481463

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