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Article

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

8 Mar 2019

Abstract excerpt

Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics of malignant cells within tumors. However, the spatiotemporal dynamics of clonal outgrowth that underlie evolutionary trajectories remain largely unresolved. Here, we sought to unravel the clonal dynamics of colorectal cancer (CRC) expansion in space and time by using a color-based clonal tracing method. This...

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PMID: 30850544
DOI: 10.1073/pnas.1813417116

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