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Developmental decrease of entorhinal gate disrupts prefrontal-hippocampal communication in immune-challenged DISC1 knockdown mice

2021-03-10

Abstract excerpt

The prefrontal-hippocampal dysfunction that underlies cognitive deficits in mental disorders emerges during early development. The contribution of the lateral entorhinal cortex (LEC), a gatekeeper of prefrontal cortex (PFC) and hippocampus (HP), to the early dysfunction is fully unknown. Here we show that the poorer LEC-dependent associative recognition memory detectable at pre-juvenile age is preceded by abnormal...

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Literature Corpus work
0576e61a-9302-5a20-91c5-336c9ddea965
DOI
10.21203/rs.3.rs-290304/v1
Open publication

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Developmental decrease of entorhinal gate disrupts prefrontal-hippocampal communication in immune-challenged DISC1 knockdown miceDOI 10.21203/rs.3.rs-290304/v1
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