Article

Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in Lipopolysaccharide-induced neuroinflammation

2024-12-30

Abstract excerpt

<title>Abstract</title> <p><bold>Objective</bold> Interleukin-37 (IL-37), an anti-inflammatory cytokine within the interleukin-1 (IL-1) family, exhibits immunomodulatory properties. Here we evaluate the effects of IL-37 on microglia in neuroinflammation and its potential mechanisms. <bold>Methods</bold> C57BL/6 mice were injected intraperitoneally with 1 μg of recombinant human IL-37 protein (rhIL-37), and 24 h l...

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Literature Corpus work: 10e3abf8-5240-5609-b5ee-5f3d36721a69
DOI: 10.21203/rs.3.rs-5692892/v1

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