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A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

2024-10-18

Abstract excerpt

Parkinson’s disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of patients. Passive immunotherapy targeting these aggregates is an attractive disease-modifying strategy. Such an approach must not only demonstrate target selectivity towards α-Sy...

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Literature Corpus work
7edca5c6-786b-5b07-9cb9-e6cef758a2f8
DOI
10.1101/2024.10.16.618734
Open publication

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A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathiesDOI 10.1101/2024.10.16.618734
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