Article

Virally encoded single-chain antibody fragments targeting alpha-synuclein protect against motor impairments and neuropathology in a mouse model of synucleinopathy

2024-09-13

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra. Affected neurons exhibit intracellular aggregates primarily composed of misfolded and phosphorylated alpha-synuclein (aSyn). In pathological conditions, this presynaptic protein has been shown to be transmitted from cell to cell in a prion-like manner, which contributes to th...

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Literature Corpus work: 3ad5d385-b67d-5f58-ac70-3d2b99d9226e
DOI: 10.1101/2024.09.09.612044

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