Article

Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

2023-07-25

Abstract excerpt

Persistent liver injury triggers a fibrogenic program that causes pathologic remodelling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and regression remain understudied. Here, we generated hepatic transcriptome profiles in two well-established liver disease models at peak fibrosis and during spontaneous regression a...

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Identifiers and source

Literature Corpus work: 7eda613f-0c69-559c-b281-6eb5b51f3e1f
DOI: 10.1101/2023.07.22.550133

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