Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

Abstract excerpt

Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and early regression remain understudied. Here, we generated hepatic transcriptome profiles in two well-established liver disease models at peak fibrosis and during spontaneous...

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• Liver Disease and Transplantation
• Liver Disease Diagnosis and Treatment
• Liver physiology and pathology