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Article

Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets

28 May 2025

Abstract excerpt

Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease characterized by chronic epithelial injury and excessive deposition of extracellular matrix (ECM) driven by dysregulated repair. Increasing evidence has shown that epithelial cell dysfunction plays a key role in PF, involving epithelial-mesenchymal transition (EMT), chronic oxidative stress, disruption of epithelial-immune interactions,...

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PMID: 40573209
DOI: 10.3390/ph18060812

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