Article
Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis.
Nature communications - 26 Sept 2022
Jaeger Benedikt, Schupp Jonas Christian, Plappert Linda, Terwolbeck Oliver, Artysh Nataliia, Kayser Gian, Engelhard Peggy, Adams Taylor Sterling, Zweigerdt Robert, Kempf Henning, Lienenklaus Stefan, Garrels Wiebke, Nazarenko Irina, Jonigk Danny, Wygrecka Malgorzata, Klatt Denise, Schambach Axel, Kaminski Naftali, Prasse Antje
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). Single cell RNA sequencing (scRNAseq) of bronchial brushes revealed extensive reprogramming of IPF-ABC towards a KRT17high PTENlow dedifferentiated cell type. In the 3D organoid model, compared to ABC obtained from...
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