Article

Airway Basal Cells show a dedifferentiated KRT17 <sup>high</sup> Phenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis

2020-09-04

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study we focus on the profibrotic properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). Single cell RNA sequencing of bronchial brushes revealed extensive reprogramming of IPF-ABC towards a KRT17 high PTEN low dedifferentiated cell type. In the 3D organoid model, compared...

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Literature Corpus work: b2cc829f-ddfb-5739-b8a9-375af5fe587b
DOI: 10.1101/2020.09.04.283408

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