Article

Amyloid beta aggregation promoted by iron leads to neuronal loss in an <i>ex vivo</i> model of Alzheimer’s disease

2025-07-16

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta (Aβ) plaques and neurofibrillary tangles. Despite well-established iron accumulation in the AD brain, its role in exacerbating Aβ toxicity is often overlooked in therapeutic research. We developed a 3D ex vivo organotypic brain slice cultures (OBSC) with Aβ monomers and ferric citrate to mimic Aβ deposits and iron o...

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Literature Corpus work: 7ec6466d-41c1-5c92-b79b-1a4b170af861
DOI: 10.1101/2025.07.11.664035

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