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Distinct regional vulnerability to Aβ and iron accumulation in post mortem AD brains

23 Aug 2024

Abstract excerpt

INTRODUCTION: The paramagnetic iron, diamagnetic amyloid beta (Aβ) plaques and their interaction are crucial in Alzheimer's disease (AD) pathogenesis, complicating non-invasive magnetic resonance imaging for prodromal AD detection. METHODS: We used a state-of-the-art sub-voxel quantitative susceptibility mapping method to simultaneously measure Aβ and iron levels in post mortem human brains, validated by...

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PMID: 39175425
DOI: 10.1002/alz.14188

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