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Article

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice.

Metallomics : integrated biometal science - 1 Mar 2018

Peters Douglas G, Pollack Alexis N, Cheng Keith C, Sun Dongxiao, Saido Takaomi, Haaf Michael P, Yang Qing X, Connor James R, Meadowcroft Mark D

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized pathologically by amyloid beta (Aβ) deposition, microgliosis, and iron dyshomeostasis. Increased labile iron due to homeostatic dysregulation is believed to facilitate amyloidogenesis. Free iron is incorporated into aggregating amyloid peptides during Aβ plaque formation and increases potential for oxidative stress surrounding...

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Identifiers

PMID: 29424844
DOI: 10.1039/c8mt00004b

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APP

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