Article

MLL4 is a critical mediator of differentiation and ferroptosis in the epidermis

2021-05-04

Abstract excerpt

<h4>ABSTRACT</h4> The epigenetic regulator, MLL4 ( KMT2D ), has been described as an essential gene in both humans and mice 1,2 . In addition, it is one of the most commonly mutated genes in all of cancer biology 3–7 . Here, we identify a critical role for Mll4 in the promotion of epidermal differentiation and ferroptosis, a key mechanism of tumor suppression 8,9 . Mice lacking epidermal Mll4 , but not the...

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Literature Corpus work: 7e918f63-cbf8-5478-a13a-3d011d0ea24a
DOI: 10.1101/2021.05.03.442432

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