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Article

2A-DUB/Mysm1 Regulates Epidermal Development in Part by Suppressing p53-Mediated Programs.

International journal of molecular sciences - 28 Feb 2018

Wilms Christina, Krikki Ioanna, Hainzl Adelheid, Kilo Sonja, Alupei Marius, Makrantonaki Evgenia, Wagner Maximilian, Kroeger Carsten M, Brinker Titus Josef, Gatzka Martina

Abstract excerpt

Development and homeostasis of the epidermis are governed by a complex network of sequence-specific transcription factors and epigenetic modifiers cooperatively regulating the subtle balance of progenitor cell self-renewal and terminal differentiation. To investigate the role of histone H2A deubiquitinase 2A-DUB/Mysm1 in the skin, we systematically analyzed expression, developmental functions, and potential...

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Identifiers

PMID: 29495602
DOI: 10.3390/ijms19030687
PMCID: PMC5877548

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