Article

RUNX1-ETO expression in epidermal keratinocytes induces progressive skin inflammation <i>in vivo</i>

2026-05-13

Abstract excerpt

Basal keratinocytes in the skin are essential for epidermal homeostasis and repair; however, how intrinsic alterations in these cells contribute to inflammatory skin pathology remains poorly understood. In this study, we employed a tamoxifen-inducible mouse model to express the human RUNX1-ETO fusion gene, a well-established oncogenic driver of acute myeloid leukemia, in epidermal basal keratinocytes. RUNX1-ETO in...

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Literature Corpus work: 937214dc-7b0c-5468-926a-a834e79b6a2a
DOI: 10.64898/2026.05.10.724156

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