Article

AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

2023-12-04

Abstract excerpt

<h4>ABSTRACT</h4> AP-2 transcription factors regulate ectodermal development but their roles for epidermal homeostasis in the adult skin are unknown. We find that AP-2α is the predominant AP-2 family member in adult epidermis, followed by AP-2β. Through inactivation of AP-2α, AP-2β, or both in keratinocytes we assessed the effects of a gradient of epidermal AP-2 activity on skin function. We find that (1) loss of...

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Literature Corpus work: a171c148-b077-5efa-bb88-880589fe5ff6
DOI: 10.1101/2023.12.03.569763

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