Article

Small Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons

2022-11-01

Abstract excerpt

<h4>SUMMARY</h4> MicroRNAs (miRNAs) are short RNAs that regulate fundamental biological processes. miR-132, a key miRNA with established functions in Tau homeostasis and neuroprotection, is consistently downregulated in Alzheimer’s disease (AD) and other tauopathies. miR-132 overexpression rescues neurodegenerative phenotypes in several AD models. To complement research on miRNA-mimicking oligonucleotides targeti...

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Literature Corpus work: 7e7cbbe7-cc72-5619-9154-e2739e7a0b4e
DOI: 10.1101/2022.11.01.514550

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