Article
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.
Acta neuropathologica - 1 Oct 2018
El Fatimy Rachid, Li Shaomin, Chen Zhicheng, Mushannen Tasnim, Gongala Sree, Wei Zhiyun, Balu Darrick T, Rabinovsky Rosalia, Cantlon Adam, Elkhal Abdallah, Selkoe Dennis J, Sonntag Kai C, Walsh Dominic M, Krichevsky Anna M
Abstract excerpt
MicroRNAs (miRNA) regulate fundamental biological processes, including neuronal plasticity, stress response, and survival. Here, we describe a neuroprotective function of miR-132, the miRNA most significantly downregulated in neurons in Alzheimer's disease. We demonstrate that miR-132 protects primary mouse and human wild-type neurons and more vulnerable Tau-mutant neurons against amyloid β-peptide (Aβ) and...
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