Article

Discovery and characterization of stereodefined PMO-gapmers targeting tau

2024-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Antisense oligonucleotides (ASOs) are an important class of therapeutics to treat genetic diseases, and expansion of this modality to neurodegenerative disorders has been an active area of research. To realize chronic administration of ASO therapeutics to treat neurogenerative diseases, new chemical modifications improving activity and safety profile are still needed. Furthermore, it is highly d...

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Literature Corpus work: cbf2d399-c082-539b-90d3-9b3793536fc0
DOI: 10.1101/2024.05.09.591947

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