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Article

MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.

PloS one - 1 Jan 2013

Jovicic Ana, Zaldivar Jolissaint Julien Francisco, Moser Roger, Silva Santos Mariana de Fatima, Luthi-Carter Ruth

Abstract excerpt

BACKGROUND: Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel. One possible explanation is that successful treatment strategy may require simultaneous targeting of more than one molecule of pathway. A new therapeutic approach to have emerged recently is the engagement of microRNAs (miRNAs), which affords the opportunity...

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Source

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Identifiers

PMID: 23349832
DOI: 10.1371/journal.pone.0054222
PMCID: PMC3547907

Genes

HDAC4
MAPK14
REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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