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Article

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation <i>in vivo</i>

11 Sept 2015

Abstract excerpt

Alzheimer's disease (AD) and related tauopathies comprise a large group of neurodegenerative diseases associated with the pathological aggregation of tau protein. While much effort has focused on understanding the function of tau, little is known about the endogenous mechanisms regulating tau metabolism in vivo and how these contribute to disease. Previously, we have shown that the microRNA (miRNA) cluster...

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PMID: 26362250
DOI: 10.1093/hmg/ddv377

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