Article
Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality.
BMC medicine - 1 Feb 2023
O'Loughlin Jessica, Casanova Francesco, Fairhurst-Hunter Zammy, Hughes Amanda, Bowden Jack, Watkins Edward R, Freathy Rachel M, Millwood Iona Y, Lin Kuang, Chen Zhengming, Li Liming, Lv Jun, Walters Robin G, Howe Laura D, Kuchenbaecker Karoline, Tyrrell Jessica
Abstract excerpt
BACKGROUND: Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depression in people of East Asian ancestry. METHODS: Multiple Mendelian randomisation (MR) methods were used to test the...
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