Article

Cryptic Last Exon splicing is a conserved tuning mechanism during neural development

2026-02-02

Abstract excerpt

Cryptic Last Exons (CLEs) are unannotated terminal exons that arise from intronic regions and their inclusion results in shorter mRNA that can be translated into truncated proteins. CLE-mRNAs have been described predominantly in neurodegenerative disease, where they are widely interpreted as pathological and a consequence of splicing dysfunction. Whether CLE-mRNAs are expressed under physiological conditions or co...

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Literature Corpus work: 7e2cc5aa-31c2-5fde-952f-6ae7eee7ca4a
DOI: 10.64898/2026.01.30.702498

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