Article

TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD

2024-01-23

Abstract excerpt

Nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 is the hallmark of ALS, occurring in over 97% of cases. A key consequence of TDP-43 nuclear loss is the de-repression of cryptic exons. Whilst TDP-43 regulated cryptic splicing is increasingly well catalogued, cryptic alternative polyadenylation (APA) events, which define the 3’ end of last exons, have been largely overlooked, especial...

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Literature Corpus work: e2bfd763-5ef3-5062-8bc4-b6baa8a6890c
DOI: 10.1101/2024.01.22.576625

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