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Article

Poison exons in neurodevelopment and disease.

Current opinion in genetics & development - 1 Dec 2020

Carvill Gemma L, Mefford Heather C

Abstract excerpt

Poison exons are naturally occurring, highly conserved alternative exons that contain a premature termination codon. Inclusion of a poison exon in a transcript targets the transcript for nonsense mediated decay, decreasing the amount of protein produced. Poison exons are proposed to play an important role in tissue-specific expression, development and autoregulation of gene expression. Recently, several studies...

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Identifiers

PMID: 32615329
DOI: 10.1016/j.gde.2020.05.030
PMCID: PMC8042789

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