Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.

doi:10.1038/s41467-020-17009-7

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Article

Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.

Nature communications - 3 Jul 2020

Ray Thomas A, Cochran Kelly, Kozlowski Chris, Wang Jingjing, Alexander Graham, Cady Martha A, Spencer William J, Ruzycki Philip A, Clark Brian S, Laeremans Annelies, He Ming-Xiao, Wang Xiaoming, Park Emily, Hao Ying, Iannaccone Alessandro, Hu Gary, Fedrigo Olivier, Skiba Nikolai P, Arshavsky Vadim Y, Kay Jeremy N

Abstract excerpt

Genes encoding cell-surface proteins control nervous system development and are implicated in neurological disorders. These genes produce alternative mRNA isoforms which remain poorly characterized, impeding understanding of how disease-associated mutations cause pathology. Here we introduce a strategy to define complete portfolios of full-length isoforms encoded by individual genes. Applying this approach to...

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Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Nerve Tissue Proteins

Share to Photoreceptor Cells, Vertebrate

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Share to Retinal Degeneration

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Identifiers

PMID: 32620864
DOI: 10.1038/s41467-020-17009-7
PMCID: PMC7335077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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