Article

A conserved role for SFPQ in repression of pathogenic cryptic last exons

2020-03-18

Abstract excerpt

The RNA-binding protein SFPQ plays an important role in neuronal development and has been associated with several neurodegenerative disorders, including ALS, FTLD, and Alzheimer’s Disease. Here, we report that loss of sfpq leads to premature termination of multiple transcripts due to widespread activation of previously unannotated cryptic last exons (CLEs). These CLEs appear preferentially in long introns of gene...

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Literature Corpus work: e5851d9c-38f1-522d-bc18-4a8053318289
DOI: 10.1101/2020.03.18.996827

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