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Article

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

26 Mar 2021

Abstract excerpt

The RNA-binding protein SFPQ plays an important role in neuronal development and has been associated with several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease. Here, we report that loss of sfpq leads to premature termination of multiple transcripts due to widespread activation of previously unannotated cryptic last exons (CLEs)....

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PMID: 33771997
DOI: 10.1038/s41467-021-22098-z

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