Article
Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2022
Norsigian Charles J, Danhof Heather A, Brand Colleen K, Midani Firas S, Broddrick Jared T, Savidge Tor C, Britton Robert A, Palsson Bernhard O, Spinler Jennifer K, Monk Jonathan M
Abstract excerpt
Combatting Clostridioides difficile infections, a dominant cause of hospital-associated infections with incidence and resulting deaths increasing worldwide, is complicated by the frequent emergence of new virulent strains. Here, we employ whole-genome sequencing, high-throughput phenotypic screenings, and genome-scale models of metabolism to evaluate the genetic diversity of 451 strains of C. difficile....
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