Article

Bespoke single cell molecular and tissue-scale analysis reveals mechanisms underpinning development and disease in complex developing cell populations

2023-10-11

Abstract excerpt

Perturbation studies using gene knockouts have become a key tool for understanding the roles of regulatory genes in development and disease. Here we systematically characterise the knockout effects of the key developmental regulators T and Mixl1 in chimeric mouse embryos during gastrulation and organogenesis. We present a comprehensive and effective suite of statistical tools for systematic characterisation of e...

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Literature Corpus work: 7e09f463-ad0d-52f2-a4a4-306c7b740584
DOI: 10.1101/2023.10.11.561904

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